

Īlong with "Sex on Fire", the song was one of two from Kings of Leon's Only by the Night to reach the top three in Australian radio station Triple J's Hottest 100 of 2008, coming in at number three. It has reappeared on further occasions since, and has now spent 77 weeks on the top 75, making it the 14th longest runner of all time, six places behind "Sex on Fire" with its 90 weeks.

In the United Kingdom, "Use Somebody" peaked at number two on the UK Singles Chart and spent an unbroken 40 weeks on the chart, only dropping out due to the surge in sales of Michael Jackson titles immediately after his death after an absence of just one week, it was back for another 20 weeks, peaking at number 25. It reached over four million downloads in the US by July 2013. "Use Somebody" also reached number one on the Adult Top 40 chart, and later topped the Mainstream Top 40 chart as well. (Preceding it were " Slide" by the Goo Goo Dolls, " Every Morning" by Sugar Ray, and " Boulevard of Broken Dreams" by Green Day.) The song first reached number one on the Billboard Hot Modern Rock Tracks chart (now called the "Alternative" chart), their second of three consecutive singles to top that chart.

On United States radio, the song was a multi-format smash, becoming just the fourth song in history to top the Mainstream Top 40, Adult Top 40, Alternative Songs, and Triple A charts. Peaking at number four on the Hot 100, it gave the band their first top five hit there, and spent 57 weeks on the chart. In the United States, "Use Somebody" became the band's mainstream breakthrough. Nick Levine of Digital Spy said, "With its Springsteen-style 'oooah-woooah's, gathering storm of guitars and lusty, longing vocals from Caleb Followill, it's nearly as infectious as ' Sex on Fire'." Gavin Haynes of NME praised the song as "easily the best 80's power ballad of 2008", but cautioned that the band "may be in danger of mistaking bluster for brilliance". Mikael Wood of Entertainment Weekly called "Use Somebody" a highlight of the album, describing the song as "a too-cool hipster's cry for comfort". The song has received generally positive reviews from music critics.
